The upper part or Fab (antigen binding) portion of the antibody molecule (physically and not necessarily chemically) attaches to specific proteins [called epitopes] on the antigen. Sesamoiditis is the name given to inflammation of the small bones behind the fetlocks, generally of the front leg. Autoimmune diseases, especially those associated with immune complexes such as systemic lupus erythematosus (SLE), often result in secondary complement deficiency due to chronic consumption that exceeds hepatic synthesis.

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